Clinical Trials

The purpose of this study is to determine the effect of a single dose of an oral acute MPO inhibitor drug on resting and exercise hemodynamics (arterial blood pressure and cardiac blood flow) in patients with heart failure with preserved ejection fraction (HFpEF).

The primary purpose of this study is to provide a subset of data using protocols of tolerance to lower-body negative pressure for validation of a commercially available wearable device that will be used in predicting hemorrhagic shock in persons suffering civilian and battlefield trauma.

The primary aim of this study is to determine if biomechanical properties of cardiac and large arterial walls measured by ultrasound-based novel imaging technology correlate with hemodynamic parameters measured by other tools in the ICU.

The purpose of this study is to determine the accuracy (sensitivity, specificity, negative predictive value, positive predictive value) of a non-invasive arterial air plethysmography prototype in people with normal and abnormal arterial hemodynamics.

The aims of this study are to correlate quantitative Lung Ultrasound (LUS) with gold-standard invasive hemodynamics during exercise in a continuous fashion, to use pulmonary thermodilution for dynamic Extravascular Lung Water (EVLW) measurements to allow direct correlation with sonographic interstitial lung thickening (B-lines) both at rest and during maximal effort exercise, and to examine how development of EVLW and B-lines relates to exercise capacity, symptoms and ventilatory control.

The purpose of this study is to investigate the overnight hemodynamic changes and impact of energy drinks on sleep in young people. 

We will collect both non-invasive hemoglobin and conventional serum hemoglobin labs from patients postoperatively following outpatient total joint arthroplasty to determine how closely the values of these two studies correlate in the outpatient total joint arthroplasty patient population.

The purposes of this study are to validate noninvasive hemoglobin monitoring in postoperative orthopedic pediatric patients, to evaluate patient, parent, and provider preference of noninvasive hemoglobin monitoring compared to invasive blood draw, and to evaluate cost effectiveness of noninvasive monitoring in comparison to invasive blood draws.

We hypothesize that (1) Patients with significant left atrial pressure (LAP) reduction during transcatheter mitral valve repair (TMVR) have lower cardiac output, more advanced diastolic dysfunction, increased left atrial stiffness, abnormal pulmonary vascular function and higher arterial afterload compared to TMVR patients without a significant LAP reduction. (2) TMVR and associated reduction in mitral regurgitation and LAP results in relief of pulmonary vascular congestion, and improvement in pulmonary vascular and right ventricular function.