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A Randomized Study Evaluating Patients Discharged with Indwelling Chest Tube and Valve
Rochester, MN
The purpose of this study is to analyze the effectiveness of antibiotics and closer monitoring on decreasing infection in patients discharging with a chest tube and valve in place.
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SURPASS: A Randomized, Double-Blind, Multicenter Study of the Efficacy, Safety, and Tolerability of Brincidofovir Versus Valganciclovir for the Prevention of Cytomegalovirus (CMV) Disease in CMV Seropositive Kidney Transplant Recipients
Rochester, MN
The purpose of this study is to compare the efficacy of brincidofovir (BCV) to valganciclovir (vGCV) for the prevention of CMV disease in kidney transplant recipients who are CMV seropositive pretransplant and received antilymphocyte induction therapy.
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A Randomized, Double-Blind, Multicenter, Phase 3 Study of the Efficacy, Safety, and Tolerability of Brincidofovir Versus Valganciclovir for the Prevention of Cytomegalovirus Disease in CMV Seronegative Kidney Allograft Recipients
Rochester, MN
To compare the efficacy of brincidofovir (BCV) to valganciclovir (vGCV) for the prevention of cytomegalovirus (CMV) disease in kidney transplant allograft recipients who are CMV seronegative pretransplant and received a kidney from a CMV seropositive donor.
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A Study of the Use of Preoperative Antibiotics Given Preventively Prior to Kidney Stone Surgery to Patients at Moderate Risk of Infection
Scottsdale/Phoenix, AZ
The purpose of this study is to determine if the use of preoperative antibiotics given to prevent infection actually decreases the postoperative risk in patients having surgery to remove kidney stones.
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Anal Occlusion and SSI Reduction
Mankato, MN
The purpose of this study is to create a special preparation protocol for the vaginal and perineal area that would include an occlusive dressing over the anal orifice (Anal Occlusive Dressing-AOD). We do hypothesize that it would eliminate or significantly reduce cross contamination of the bowel content with the surgical site and hence reduce the risk of SSI.
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Study of Rezafungin Compared to Standard Antimicrobial Regimen for Prevention of Invasive Fungal Diseases in Adults Undergoing Allogeneic Blood and Marrow Transplantation (ReSPECT)
Rochester, MN
The primary objective of the United States Food and Drug Administration (FDA) for this study is to demonstrate non-inferiority in subjects who received an allogeneic BMT for subjects randomized to Rezafungin for Injection compared to subjects randomized to the standard antimicrobial regimen (SAR) for fungal-free survival at Day 90 (±7 days).
The primary objective of the European Medicines Agency (EMA) for this study is to demonstrate superiority in subjects who received an allogeneic BMT randomized to Rezafungin for Injection compared to subjects randomized to the SAR for fungal-free survival at Day 90 (±7 days).