Clinical Trials

The purpose of this study is to perform an in-depth review of pre-operative considerations and indications for spinal cord stimulation (SCS) for refractory angina pectoris (RAP), intraoperative findings, and postoperative reports of any adverse events and (secondarily) patient reports of effectiveness with this therapy.

The purpose of this study is to evaluate if subjects who have already experienced tonic spinal cord stimulation would have a better pain relief status with burst spinal cord stimulation

The purpose of this study is to determine the rate at which patients who underwent Spinal Cord Stimulation (SCS) trial ultimately progressed to SCS implantation, determine the percentage of patients who continued using their SCS system after 5 years, as well as identify patient characteristics that lead to SCS discontinuation.

The purpose of this study is to assess painful diabetic peripheral neuropathy after high-frequency spinal cord stimulation.

The purpose of this study is to compare transcutaneous electrical spinal stimulation and epidural electrical spinal stimulation.  Relationships between stimulation input and electrophysiological output will be recorded, and changes in motor, sensory, and functional outcomes during and after stimulation will be assessed.

The purpose of this study is to characterize and compare sensorimotor activity in muscles below the level of injury during Transcutaneous Epidural Spinal Stimulation (TESS) and Epidural Electrical Stimulation (EES)-enabled motor tasks, and to assess and compare changes in clinical outcomes over the course of rehabilitation with TESS and EES.

The purpose of this study is to document the safety, clinical effectiveness and cost-effectiveness of high-frequency HF10™ Therapy, delivered through the Senza system, in subjects with chronic refractory back pain (with or without leg pain) who are not considered candidates for spine surgery. This study is a multi-center, prospective, randomized study to compare the two treatment groups.

The purpose of this study is to evaluate the effectiveness of BurstDRTM spinal cord stimulation, compared with comprehensive medical management, in improving pain and back-related physical function in patients suffering with chronic, refractory axial low back pain with a neuropathic component, who have not had lumbar spine surgery and for whom surgery is not an option.

The purpose of this study is to provide confirmatory evidence that use of the LIFT System, inclusive of all components and accessories, is safe; to provide confirmatory evidence that use of the LIFT System provides an effective treatment for the restoration or improvement in UE strength and function; and to provide data regarding the potential benefits of the LIFT System to achieve other secondary outcomes such as improvement in pain, spasticity, quality of life, cardiovascular (blood pressure) and autonomic function.

The study is being conducted to gain a broader understanding of how Abbott’s neurostimulation systems are being used in the real-world setting. It will serve the dual purpose of collecting long-term safety and effectiveness of these devices and obtaining information about the different patient populations who are using them.

The purpose of this study is to document the safety, clinical effectiveness and cost-effectiveness of high-frequency SCS at 10 kHz (HF10™ Therapy) delivered through the Senza system in subjects with chronic refractory back pain (with or without leg pain) who are not considered candidates for spine surgery. This study is a multi-center, prospective, randomized study to compare the two treatment groups.

The purpose of this study is to understand pain outcomes in patients with cancer who have Chemotherapy-Induced Peripheral Neuropathy (CIPN).

To evaluate the safety and effectiveness of the Precision Spinal Cord Stimulator System Adapted for High-Rate Spinal Cord Stimulation as an aid in the management of chronic intractable pain

The purpose of this study is to determine if epidural spinal cord stimulation can affect blood pressure control and blood vessel resistance during exercise in heart failure patients by intercepting messages of muscle fatigue and shortness of breath.

A study to compare electrophysiologic activity of epidural stimulation and dorsal root ganglion stimulation, as well as quantify changes in motor performance with both types of stimulation over the course of 10 rehabilitation sessions.

The proposed study is intended to inform the hypotheses that (1) regular dosing of exoskeleton walking will provide health benefits to non-ambulatory and poorly-ambulatory individuals with SCI, including decreased pain and spasticity, improvements in bowel and bladder function, decreased body-mass index (BMI), enhanced well-being; (2) regular dosing of exoskeleton walking will facilitate neurological or functional recovery in some individuals with SCI, particularly those with incomplete injuries; and (3) the level of mobility enabled by a lower limb exoskeleton is commensurate with the walking speeds, distances, and surfaces required for community ambulation.