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A Study of the Role of the Forkhead Box O3a BNIP3 Pathway in Human Cardiovascular Disease
Rochester, MN
The purpose of this study is to collect cardiac biopsies and assess the activity of the signaling pathway in patients with cardiovascular disease by using transmission electron microscopy to study mitochondrial structure and morphology and by assessing the biology of the genes and proteins of the FOXO3a effector, BNIP3.
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Inherited Muscle Diseases Repository
Rochester, MN
To establish a repository of DNA samples collected prospectively from patients with inherited myopathies of unknown molecular and/or biochemical defect. To access residual muscle specimens from diagnostic muscle biopsies obtained as part of the routine medical care. The biospecimens will be used to better understanding the underlying molecular defects and mechanisms of muscle diseases.
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A Study Investigating Integrated Genomics and Patient-derived Cancer Models
Scottsdale/Phoenix, AZ; Jacksonville, FL; Rochester, MN
The aim of this project is to characterize a landscape of DNA alterations and proteomic changes in both biopsies and resected tumors of patients which have been diagnosed with aggressive/metastatic disease to identify molecular targets for which therapeutic drugs may exist.
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Image-based Mapping of Brain Tumors
Scottsdale/Phoenix, AZ; Rochester, MN
The purpose of this study is to combine MRI images with histologic and genetic analysis of cancer (from blood and tissue samples) to improve the overall accuracy of diagnosis and effectiveness of cancer treatment.
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3D Ultrasound for the Imaging of Axillary Lymph Nodes in Patients With Breast Cancer
Rochester, MN
The overall goal of this project is to study a new 3D ultrasound imaging technology for evaluation of axillary lymph nodes in patients with breast cancer.