Purna C. Kashyap, M.B.B.S.

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SUMMARY

Purna C. Kashyap, MBBS, studies the complex interactions between gut bacteria and dietary carbohydrates and their influence on host physiological function, such as gastrointestinal motility. The long-term goal of Dr. Kashyap's research is to develop new biomarkers and microbiota-targeted therapies for treatment of functional gastrointestinal disorders, including irritable bowel syndrome associated with altered gastrointestinal motility.

Focus areas

• Identifying and developing microbiota-targeted therapies for treatment of functional gastrointestinal disorders (FGID), such as irritable bowel syndrome and functional bloating
• Understanding the mechanisms by which fecal microbiota transplant helps restore altered microbial profiles in diseases such as Clostridium difficile colitis to develop enhanced therapeutic strategies

Significance to patient care

Dr. Kashyap's research aims to better understand the pathogenesis of functional gastrointestinal disorders and develop newer treatment options for patients. The current understanding of the disease process remains poor, and as a result treatment options are very limited and fail to address the underlying causes. Dr. Kashyap and his team hope to extend this knowledge to address other diseases associated with changes in human gut bacteria.

Professional highlights

• Bernard and Edith Waterman Director, Microbiome Program, Center for Individualized Medicine, Mayo Clinic, 2023-present.