Assessing the Efficacy of Steroid Treatment of Achalasia

Overview

About this study

Would systemic steroids be an effective treatment in early variants of achalasia?

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion criteria:

Adults ages 18-90 with a diagnosis of achalasia confirmed by findings on esophageal manometry and barium esophagogram will be eligible for the study.
Eckardt score6 greater or equal to 6 or 2 or greater for dysphagia and/or regurgitation
Symptoms less than 2 years

Exclusion criteria:

Medical conditions such as severe heart or lung disease that preclude safe performance of endoscopy and injection;
Greater than mild esophageal dilation
Type 1 achalasia as defined by the Chicago classification scheme7 and/or esophageal diameter > 3cm;
Prior treatment for achalasia
Use of medications that might affect LES pressure such as anticholinergics or calcium channel antagonists
Symptom duration greater than 2 years
Inability to read due to: Blindness, cognitive dysfunction, or English language illiteracy
Disorders which predispose to unreliable responses such as Schizophrenia, Alzheimer's disease or significant memory loss
Pregnant and lactating females will be excluded as steroids are not thought safe for the fetus.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Karthik Ravi, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Karthik Ravi, M.D.

Closed for enrollment

More information

Publications

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