Does Tranexamic Acid Reduce the Need for Blood Transfusions in Patients Undergoing Hip Fracture Surgery?

Overview

About this study

Does tranexamic acid improve the perioperative care of those patients treated surgically for hip fracture by decreasing the proportion of patients requiring transfusion and decreasing total perioperative bleeding?

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion criteria

AO/OTA (Orthopedic Trauma Association) fracture classification 31B
Surgically treated with either hemiarthroplasty or total hip arthroplasty
Acute fracture treated within 72 hours of injury
Low energy isolated injury
Age greater than 18 years old

Exclusion Criteria

Transfusion received during admission, prior to surgery
Creatinine clearance less than 30 mL/min
History of unprovoked Venous Thromboembolism (VTE) and/or recurrent VTE
Known history of Factor V Leiden, protein C/S deficiency, prothrombin gene mutation, anti-thrombin deficiency, anti-phospholipid antibody syndrome, lupus anticoagulant
Pregnancy or breastfeeding (pregnancy tests will be performed on all patients of child-bearing potential)
History of cerebrovascular accident (CVA), Myocardial infarction (MI), or VTE within the previous 30 days
Coronary stent placement within the previous 6 months
Disseminated intravascular coagulation
Subarachnoid hemorrhage

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Mark Pagnano, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Mark Pagnano, M.D.

Closed for enrollment

More information

Publications

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