Muscle Protein Metabolism in Obesity

Overview

About this study

Obesity is associated with reduced adenosine triphosphate (ATP) turnover in skeletal muscle, a condition that can impair muscle metabolism. The proposed research will discover mechanisms responsible for decreased content in mitochondrial proteins as well as in protein β-F1-ATPase, which is directly responsible for ATP assembly, in the muscle of obese individuals. This research will further examine the effectiveness of interventions, such as increased plasma amino acid availability and exercise, to increase the rate of production of mitochondrial proteins as well as that of β-F1-ATPase in the muscle of obese individuals. The findings will help to develop appropriate interventions to improve muscle ATP turnover and metabolism in obese people.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion criteria:

Body mass index (BMI): lean, 19-25 kg/m2; obese, 30-40 kg/m2
Availability of transportation
Ability to sign informed consent form

Exclusion criteria:

Medication or supplements (i.e. amino acids, protein) known to affect protein metabolism
Presence of acute illness
History of liver disease
Uncontrolled metabolic disease
ECG documented abnormalities, atrial fibrillation, history of syncope, limiting or unstable angina, or congestive heart failure
Chronically elevated blood pressure (systolic, >140 mmHg; diastolic, >100 mmHg)
Cardiac pacemaker or other medical device implanted in the body
Low hemoglobin or hematocrit
Current participation in a weight-loss regimen, including extreme dietary practices
Smoking
Use of anabolic steroids or corticosteroids (within 3 months)

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Scottsdale/Phoenix, Ariz. Mayo Clinic principal investigator Lori Roust, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Lori Roust, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

Clinical Trials