The Effect of Intranasal Vasoconstrictor Medications on Hemodynamic Parameters: A Randomized Double-blind, Placebo-controlled Trial.

Overview

About this study

Inclusion Criteria:

Healthy volunteers over the age of eighteen that have been recently dismissed from the Emergency Department at Mayo Clinic Hospital, Saint Marys Campus.
We will recruit a convenience sample of 100 patients from the Emergency Department who have completed their Emergency Department evaluation and treatment and are being discharged to home with non-painful conditions.

Exclusion Criteria:

We will exclude persons under the age of eighteen
Vulnerable populations (pregnant patients and prisoners)
Those with an allergy to any of the study agents
Those with acute pain
Those using antihypertensive or antiarrhythmic agents
Those with significant cardiopulmonary comorbidities (namely history of arrhythmia, coronary artery disease, hypertension, and heart failure)
Those with concomitant use of MAO-Inhibitors
Those with a diagnosis of angle closure glaucoma or BPH
Those with a history of cerebrovascular disease
As well as those with a history of previous nasal surgery or known nasal anatomic abnormalities.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Healthy volunteers over the age of eighteen that have been recently dismissed from the Emergency Department at Mayo Clinic Hospital, Saint Marys Campus.
We will recruit a convenience sample of 100 patients from the Emergency Department who have completed their Emergency Department evaluation and treatment and are being discharged to home with non-painful conditions.

Exclusion Criteria:

We will exclude persons under the age of eighteen
Vulnerable populations (pregnant patients and prisoners)
Those with an allergy to any of the study agents
Those with acute pain
Those using antihypertensive or antiarrhythmic agents
Those with significant cardiopulmonary comorbidities (namely history of arrhythmia, coronary artery disease, hypertension, and heart failure)
Those with concomitant use of MAO-Inhibitors
Those with a diagnosis of angle closure glaucoma or BPH
Those with a history of cerebrovascular disease
As well as those with a history of previous nasal surgery or known nasal anatomic abnormalities.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Tobias Kummer, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Tobias Kummer, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

Clinical Trials