Identification of a Plasma Proteomic Signature for Lung Cancer

Overview

About this study

The primary objective is to identify a panel of plasma and/or serum proteins that differentiates the absence or presence of lung malignancy in samples obtained from subjects enrolled in this IRB/EC approved study with pulmonary nodules.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

age ≥ 40
any smoking status, e.g. current, former, or never
co-morbid conditions, e.g. COPD
Nodule size ≥ 4 mm and ≤ 30 mm (up to Stage 2B eligible), any spiculation or ground glass opacity
Pathology: malignant - adenocarcinoma, squamous, or large cell
Pathology: benign - inflammatory (e.g. granulomatous, infectious) or non-inflammatory (e.g. hamartoma)
Clinical stage, Primary tumor: ≤T2 (e.g. 1A, 1B, 2A and 2B)
Clinical stage, Regional lymph nodes: N0 or N1 only
Clinical stage, Distant metastasis: M0 only

Exclusion Criteria:

prior malignancy within 5 years of lung nodule diagnosis
No nodule size available
No pathology data available for those with
Current diagnosis of non-small cell lung cancer
Clinical stage: Primary tumor ≥T3; Regional lymph nodes: ≥N2; 4 Distant metastasis: ≥M1

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Scottsdale/Phoenix, Ariz. Mayo Clinic principal investigator David Midthun, M.D.	Closed for enrollment
Rochester, Minn. Mayo Clinic principal investigator David Midthun, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

David Midthun, M.D.

Closed for enrollment

Rochester, Minn.

Mayo Clinic principal investigator

David Midthun, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

Clinical Trials