Clinical Trials

Normal Subjects Inclusion Criteria

• Volunteers without epilepsy or CNS disease other than primary headache disorder.
• Ages  5-55 years
• Adult subjects able to tolerate an unsedated MRI on MR 41 (Siemens Skyra) and possibly a 2nd MRI on MR 37 (GE), and, further, possibly a 3rd MRI (one sequence only) on MR 41.
• Pediatric subjects (5-17 years) able to tolerate an unsedated MRI on MR 37.
• Able to tolerate a wake/sleep EEG.
• Previously received medical care at Mayo Rochester and consents to medical information review

Normal Subjects Exclusion Criteria 

• Prior history of seizures or epilepsy
• Prior history of other central nervous system disease other than primary headache disorder
• Prior intracranial surgical procedure
• Presence of implanted devices on Radiology’s list of incompatible devices or those in which non-routine MRI processes or procedures are required
• Chronic neck or back pain, restless legs syndrome, movement disorders, claustrophobia, or other medical problems that would interfere with the patient laying still in the scanner
• Does not consent to review of medical information
• Pregnancy
• Imbedded intraorbital or scalp metallic foreign body
• Weight greater than 300 pounds

Epilepsy Cases Inclusion Criteria

• Volunteers with epilepsy
• Ages 5-70 years
• Adult subjects able to tolerate an unsedated MRI on MR 41 (Siemens Skyra).
• Pediatric subjects (5-17 years) able to tolerate an unsedated MRI on MR 37.
• Previously received medical care at Mayo Rochester and consents to medical information review

Epilepsy Cases Exclusion Criteria 

• Prior history of other central nervous system disease other than primary headache disorder or epilepsy
• Prior intracranial surgical procedure
• Presence of implanted devices on Radiology’s list of incompatible devices or those in which non-routine MRI processes or procedures are required
• Chronic neck or back pain, restless legs syndrome, movement disorders, claustrophobia, or other medical problems that would interfere with the patient laying still in the scanner
• Does not consent to review of medical information
• Pregnancy
• Imbedded intraorbital or scalp metallic foreign body
• Weight greater than 300 pounds