Clinical Trials

Inclusion Criteria:

• first time ST elevation anterior STEMI
• Significant chest discomfort and /or shortness of breath
• ST segment elevation (1.5 mV total) in two or more adjacent anterior precordial leads
• Successful reperfusion therapy (>TIMI grade 2 flow) either with thrombolytics or PTCA within 24 hours of onset of symptoms as documented by coronary angiography
• No previous history of an anterior AMI or previous ECG suggesting an old anterior AMI.

Exclusion Criteria:

• Cardiogenic shock, acute heart failure or hypotension (Systolic BP < 90 mmHg)
• Previous MI
• Previous known decreased EF < 40%
• Atrial Fibrillation
• Persistent signs and symptoms of Post MI ischemia
• Requirement of pressors for maintenance of blood pressure.
• Intra-aortic blood pump use
• Significant (moderate-severe) valvular stenosis, hypertrophic, restrictive or obstructive cardiomyopathy, constrictive pericarditis, primary pulmonary hypertension.
• Severe congenital heart diseases
• Sustained ventricular tachycardia or ventricular fibrillation
• Second or third degree heart block without a permanent cardiac pacemaker
• Stroke within 3 months or other evidence of significantly compromised CNS perfusion
• Total bilirubin of > 2.5 mg/dL or other liver enzymes >2.5 times the upper limit of normal
• Patients with calculated GFR <30 ml by MDRD equation or those with acute kidney injury as defined by an increase of plasma creatinine of 0.5 mg/dL from a plasma creatinine measured within the last 7 days
• Serum sodium of < 125 mEq/dL or > 160 mEq/dL
• Serum potassium of < 3.0 mEq/dL or > 5.8 mEq/dL
• Hemoglobin < 8.5 gm/dl
• Other acute or chronic medical conditions or laboratory abnormality which may increase the risks associated with study participation or may interfere with interpretation of the data
• Received an investigational drug within 1 month prior to dosing
• Female subject who is pregnant or breastfeeding
• Unable to undergo cardiac MRI
• In the opinion of the investigator, is unlikely to comply with the study protocol or is unsuitable for any reasons