Effect of Vitamin D Supplementation on Endothelial Function in Obese Adolescents

Overview

About this study

Vitamin D deficiency has been linked to endothelial dysfunction in adults. Obese adolescents have a high prevalence of Vitamin D deficiency as well as evidence of endothelial dysfunction. Our hypothesis is that supplementation of Vitamin D deficient adolescents with Vitamin D would lead to improvement in endothelial dysfunction.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Age 12-18 years
BMI >95% for age and gender
25 (OH) D levels less than 30 ng/ml

Exclusion Criteria:

25 (OH) D levels >30 ng/mL
Serum calcium >10.4 mg/dL
Serum phosphorus > 4.7 mg/dl
Pregnancy or nursing
Current cancer
Patients on vitamin D3 supplementation exceeding 400 IU/day
Hypertension defined as Blood Pressure over the 95th percentile for age, gender and height
Dietary calcium intake exceeding 1500 mg/day,
Hepatic or renal disorders
Type 1 or type 2 diabetes mellitus
Subjects receiving insulin, metformin, or oral hypoglycemic medications
Subjects with malabsorption disorders (celiac disease, cystic fibrosis,inflammatory bowel disease)

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Seema Kumar, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Seema Kumar, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

Clinical Trials