A Study Using Genetic Panel to Assist in Diagnosis of Hereditary Young Onset Dementia

Overview

About this study

The purpose of this study is to use a specific gene panel to assist in the diagnosis of a hereditary form of young onset dementia.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

Have a dementia syndrome with onset prior to age 60 years
Felt to be degenerative on clinical grounds
Have had a standard Mayo Clinic dementia evaluation including
- Structural brain imaging
- Complete blood counts
- Metabolic panel
- Thyroid function
- Vitamin B12 levels
Through June 30, 2015, additional testing will be required given the young age of onset including
- spinal fluid examination for possible chronic meningoencephalitic causes of progressive cognitive decline
- electroencephalography
Additionally, any patients with positive biomarker tests (amyloid or fluorodeoxyglucose PET, CSF biomarkers) will be preferred
After June 30 these additional tests will be encouraged but no longer required to maximize enrollment during the funding period
Patients and families will have to agree to disclosure of results

More information

Publications

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Clinical Trials