A Study of Pre-Conditioning Prior to Surgery to Improve Functional and Clinical Outcomes in Patients with Aortic Stenosis

Overview

About this study

The purpose of this study is to evaluate whether simple cardiac exercise interventions to improve physical performance before transcatheter aortic valve replacement (TAVR) surgery improves outcomes after TAVR.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

Eligibility for TAVR
SPPB < 9
Able to exercise
Able to come for follow-up visits
Able to give informed consent

Exclusion Criteria

New York Heart Association (NYHA) Class III/IV congestive heart failure (CHF)
Presyncope or syncope as presentation
Acute coronary syndrome
Unable to exercise
Dementia
Sustained ventricular arrhythmia
Stroke with neurological deficit
Advanced Parkinson's
Participated in an exercise program

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Eau Claire, Wis. Mayo Clinic principal investigator Deaglan O'Cochlain, M.D.	Closed for enrollment
Rochester, Minn. Mayo Clinic principal investigator Mandeep Singh, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Eau Claire, Wis.

Mayo Clinic principal investigator

Deaglan O'Cochlain, M.D.

Closed for enrollment

Rochester, Minn.

Mayo Clinic principal investigator

Mandeep Singh, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

Clinical Trials