Clinical Trials

Inclusion Criteria:

• Age 40-80 years old.
• Chronic kidney disease estimated glomerular filtration rate (eGFR)15-45 ml/min/1.73m2.
• Diabetes mellitus and taking diabetes medications.

Exclusion Criteria:

• Concomitant glomerulonephritis.
• Nephrotic syndrome.
• Solid organ transplantation.
• Autosomal dominant or recessive polycystic kidney disease.
• Known  renovascular disease.
• Pregnancy.
• Active immunosuppression therapy.
• Hemoglobin A1c ≥ 10% at screening.
• History of active substance abuse (including alcohol) within the past 2 years.
• Current alcohol abuse (> 3 alcoholic beverages/day or > 21 per week).
• Body weight > 150 kg or body mass index (BMI) > 50.
• Human immunodeficiency virus infection.
• Active hepatitis B or C infection.
• Tyrosine kinase inhibitor therapy.
• Known hypersensitivity or allergy to dasatinib or quercetin.
• Inability to give informed consent.
• Uncontrolled systemic lupus erythematosus.
• Uncontrolled pleural/pericardial effusions or ascites.
• New invasive cancer except non-melanoma skin cancers.
• Invasive fungal or viral infection.
• Inability to tolerate oral medications.
• Total bilirubin > 2x upper limit of normal.
• Subjects taking medications that are sensitive to substrates or substrates with a narrow therapeutic range for CYP3A4, CYP2C8, CYP2C9, or CYP2D6 or strong inhibitors or inducers of CYP3A4 (e.g. cyclosporine, tacrolimus or sirolimus). antifungals are absolutely necessary from an infectious disease perspective, then they will be allowed only if the levels aretherapeutic.
• Strong inhibitors of CYP3A4.
• Subjects on therapeutic doses of anticoagulants (Warfarin (Coumadin);Rivaroxaban (Xarleto);Apixaban (Eliquis); Dabigatran (Pradaxa, Prazaxa) or Other).
• Subjects on antiplatelet agents ((Clopidogrel (Plavix); Dipyridamole + Asprin (Aggrenox); Ticagrelor (Brilinta); Prasugrel (Effient); Ticlopidine (Ticlid) orOther) who are unable or unwilling to reduce or hold therapy prior to and during the 2-day drug dosing. Subjects may continue their previous regimen on day 3.
• Subjects on quinolone antibiotic therapy for treatment or for prevention ofinfections within 10 days.
• Subjects taking H2-antagonists or proton pump inhibitors and unwilling to discontinue therapy for 1 week before and 2 weeks following enrollment.
• QTc > 450msec.
• Presence of any condition that the Investigator believes would put the subject at risk or would preclude the patient from successfully completing all aspects of the trial.
• *Active immunosuppression therapy may include common systemic drugs such as tacrolimus, sirolimus, cyclosporin, rituximab (or other monoclonal antibodies), mycophenolate mofetil. Most potential subjects on these medication therapies will be identified through the exclusion criteria outlined above.
• Involvement of special vulnerable populations:
  • We will not involve special vulnerable populations, such as fetuses, neonates, pregnant women, children, prisoners, institutionalized individuals, or others who may be considered vulnerable populations.