Clinical Trials

Inclusion Criteria:

- Must be over the age of 18

- Must speak English as your primary language

- Must have an informant who can provide independent evaluation of functioning

- Must present with a chief complaint of progressive impairment of speech/language or
changes in behavior

- Must fulfill diagnostic criteria for Primary Progressive Aphasia or Frontotemporal
Dementia

Exclusion Criteria:

- Any subject who is mute or whose speech is unintelligible will be excluded

- All subjects with concurrent illnesses that could account for speech and language
deficits, such as traumatic brain injury, strokes or developmental syndromes, and
subjects meeting criteria for another neurodegenerative disease, such as amnestic
Alzheimer's type dementia, dementia with Lewy bodies, progressive supranuclear palsy,
and corticobasal syndrome will be excluded

- All pregnant, post-partum and breast-feeding women will be excluded

- Subjects will also be excluded if MRI is contraindicated (metal in head, cardiac pace
maker, etc.), if there is severe claustrophobia, if there are conditions that may
confound brain imaging studies (e.g. structural abnormalities, including subdural
hematoma or intracranial neoplasm), or if they are medically unstable or are on
medications that might affect brain structure or metabolism,(e.g. chemotherapy).

Note: Other protocol defined Inclusion/Exclusion criteria may apply.

Eligibility last updated 7/18/23. Questions regarding updates should be directed to the study team contact.