Clinical Trials

Inclusion Criteria:

• Age: 18 to 65 years old (inclusive).
• Gender: both males and females.
• Body mass index (BMI): 18.5-34.9 kg/m^2.
• Habitual sleep duration < 7 hours.
• Presence of either:
  • Prehypertension: office systolic BP (SBP) 120-139 mmHg and/or diastolic BP (DBP) 80-89 mmHg;
  • Stage 1 hypertension: office SBP 140-159 mmHg and/or DBP 90-99 mmHg.
• Either on no prescription medications (other than oral contraceptive pills, or intrauterine devices) or on stable medical regimen for at least 1 month, if taking prescription medications for chronic conditions.
• Not pregnant or breast feeding and not intending to become pregnant or breast feed.
• Not a current smoker or tobacco user.
• Ability to provide written informed consent.

Exclusion Criteria:

• Vulnerable study populations will be excluded.
• Pregnancy.
• Smoking.
• Presence of overt cardiovascular diseases, diabetes, chronic kidney disease, cancer, sleep disorders, psychiatric disorders.
• If taking prescription medications for chronic conditions, change in therapy (type, frequency and/or dosage) over the previous month.
• Habitual sleep duration ≥ 7 hours.
• Excessive alcohol (≥ 15 drinks/week in men and ≥ 8 drinks/week in women) and/or excessive caffeine intake (> 400 mg).
• Currently on a diet and/or actively trying to lose weight.
• Currently or previously (during the past 2 months) participation in any other research study at the discretion of study personnel.
• Blood/plasma donation during the past 2 months.
• Unwillingness or inability to adjust sleep schedule.