A Study Using Ultrasound Surface Wave Elastography to Measure Tissue Thickness and Elasticity in Eyes with Glaucoma

Overview

About this study

The purpose of this study is to use Ultrasound surface wave elastography to measure and compare the tissue thickness and elasticity in normal eyes and eyes with glaucoma. The goal is to understand the association between tissue characteristics and glaucoma.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

Either gender
Any self-declared ethnoracial category
Greater than or equal to 18 years of age
Ability to cooperate for examinations required for study
Normal subjects
- Healthy eyes with the crystalline lens
- Without glaucoma (cup:disc ratio < 0.6 both eyes. Asymmetry of cup:disc ratio between eyes < 0.2)
- Without any other clinically significant eye diseases
- Open angles
Glaucoma patients
- Newly diagnosed glaucoma patients (POAG, NTG, and pseudoexfoliative glaucoma)
- Without any previous anti-glaucomatous treatment
- Medically treated glaucoma patients who can safely stop medication for 6 weeks
  - MD > -10dB on standard automated perimetry
  - No central scotoma
  - Pre-treatment IOP ≤ 35 mmHg
  - Using two or less medications

Exclusion Criteria

Chronic or recurrent inflammatory eye diseases
Ocular trauma within the past 6 months
Ocular infection or ocular inflammation in the past 3 months
Clinically significant retinal disease
Cornea pathologic changes preventing reliable measurement (scarring, opacity)
Previous intraocular surgery
Previous corneal refractive surgeries
Serious hypersensitivity to topical anesthetic medication

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Arthur Sit, M.D., M.S.	Open for enrollment	Contact information: Jessica Morgan C.O.A. (507) 293-9689 Morgan.Jessica@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Arthur Sit, M.D., M.S.

Open for enrollment

Contact information:

Jessica Morgan C.O.A.

(507) 293-9689

Morgan.Jessica@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials