Clinical Trials

Inclusion Criteria

• Adults 18-90 years of age
• Miller Class I & II defects on 1 to 4 adjacent teeth in either the maxillary or mandibular arch
• At least 1 adjacent non-involved tooth on either side of the included recession defects
• Keratinized tissue width of ≥ 2.0 mm
• Periodontal probing depths of 3 mm or less on included teeth
• Plaque index of 2 or less
• Bleeding on probing at 30% or less sites
• Current non-smoker
• No active infected wounds

Exclusion Criteria

• Less than 18 years of age
• Miller Class III, or IV mucogingival defects
• Miller Class I & II defects on greater than 4 adjacent teeth
• Miller Class I & II defects without adjacent non-involved teeth
• CEJ not identifiable
• Root surface restoration at the defect site
• Periodontal probing depths greater than 3 mm
• Plaque index of 2 or greater
• Bleeding on probing at more than 30% of sites
• Uncontrolled oral disease
  • Moderate to severe generalized chronic or aggressive periodontitis
  • Oral manifestations of a systemic disease
• History of previous root coverage procedure, graft, or GTR
• Current smoker or other tobacco use
• Alcohol abuse problems
• Traumatic occlusion impinging on the recession defect
• Use of intraoral appliances that impinge on the recession defect
• Intra-oral piercings that impinge on the included defect
• Uncontrolled systemic health conditions
  • Debilitating systemic or infectious disease
  • Diabetes
  • Heart Disease
  • Uncontrolled heart disease
  • Delayed wound healing
  • Immunocompromised status due to medication or immune system dysfunction
  • Active infection or non-healing wounds
• Currently pregnant or lactating
• Long-term steroid use
• Allergies to bovine products or collagenous materials
• Requirement of prophylaxis antibiotics
• Failure to follow the study protocol