A Study of Prolactin Levels in Women with Chronic Migraine

Overview

About this study

The purpose of this study is to identify whether there is a difference in prolactin levels between patients with chronic migraine and healthy controls. This may help to explain the sensitivity to pain those patients with chronic migraine experience and may also help to establish a target for new treatments of chronic migraine

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

Cases
- Female
- Age 18-50 years
- Diagnosis of chronic migraine as defined by the ICHD III beta criteria
- Must self-report a typically regular menstrual cycle
Controls
- Female
- Healthy
- Age 18-50 years
- Must self-report a typically regular menstrual cycle

Exclusion Criteria

Cases
- Has significantly elevated anxiety and depression inventory scores (GAD-7 score of 10 or higher and PHQ-9 score of 10 or higher)
- Self-reports an unreliable menstrual cycle
- A history of a pituitary adenoma or history of spontaneous galactorrhea
- Has known hyperprolactinemia
- Currently taking medications which can affect serum prolactin levels (drugs are listed below)
- Pregnant or breastfeeding
- History of schizophrenia or psychosis
Controls
- Has significantly elevated anxiety and depression inventory scores (GAD-7 score of 10 or higher and PHQ-9 score of 10 or higher)
- Of reproductive age with menstrual cycles impossible to predict
- A history of pituitary adenoma or history of spontaneous galactorrhea
- Has known hyperprolactinemia
- Currently taking any drugs which can affect serum prolactin levels (drugs are listed below)
- Pregnant or breastfeeding
- History of schizophrenia or psychosis
Drugs that affect prolactin levels that will exclude both cases and controls
- Chlorpromazine
- Fluphenazine
- Haloperidol
- Loxapine
- Perphenazine
- Pimozide
- Thiothixene
- Trifluoperazine
- Aripiprazole
- Asenapine
- Clozapine
- Ilperidone
- Lurasidone
- Olanzepine
- Paliperidone
- Quetiapine
- Risperidone
- Ziprasidone
- Amitriptyline
- Desipramine
- Clomipramine
- Metoclopramide
- Domperidone
- Prochrlorperazine
- Verapamil
- Methyldopa
- Methadone
- Morphine
- Hydropmorphone
- Oxydocone
- Hydrocodone
- Codeine

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Scottsdale/Phoenix, Ariz. Mayo Clinic principal investigator Amaal Starling, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Amaal Starling, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

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