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Characterizing HIV-related Diastolic Dysfunction

Overview

About this study

The purpose of this study is to better understand how the heart’s health and function is affected by HIV infection and use of active antiretroviral therapy.

 

 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  1. Age >40 years
  2. Willingness and ability to provide informed consent
  3. HIV antibody positive
  4. On HAART for >6 months (HIV positive cohort only)
  5. History of adequate viral suppression as defined by HIV RNA level <200 copies/mL in the past 6 months
  6. LVEF >50% -

Exclusion Criteria:

  1. Past EF <50%
  2. Moderate or severe valve stenosis or regurgitation, or past repair or replacement
  3. Percutaneous or surgical revascularization or active angina
  4. Persistent atrial fibrillation
  5. BP>160mmHg SBP or >100mmHg DBP
  6. Comorbid inflammatory disease (e.g. RA or SLE)
  7. Active cancer or cancer chemotherapy treatment in the prior year (except skin cancer that did not require chemotherapy or radiation)
  8. Chronic use of steroids or anti-inflammatory therapy
  9. GFR <30 mL/min
  10. Active in a clinical trial with investigational product
  11. Pregnant or lactating females
  12. Contraindication to cMR or gadolinium injection (such as severe claustrophobia, metal implants, etc.)

 

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Margaret Redfield, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

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CLS-20271296

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