A Study of Systemic Markers of Inflammation and Neural Injury in Healthy Controls

Overview

About this study

The role of the immune system in epilepsy is currently unknown. We also do not know if neurons (nervous system cells) are injured in patients with epilepsy during seizures. The purpose of this study is to measure markers of immune activation and neuronal injury in your blood so that we can compare the levels of these factors in healthy individuals to the levels measured in patients with epilepsy. A specific component of this study is the collection of blood from healthy subjects at 5 different times during the same day (6 AM, 9 AM, 12 PM, 3 PM, 6 PM). This is different than the way most healthy control samples are collected. Repeated collection of blood from healthy subjects is important because this is how we collect and analyze samples in patients with epilepsy. We need to know if the changes we have observed in epilepsy patients are caused by seizures or whether such changes can occur simply as the result of repeated measurements or time of day.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Healthy adults between the ages of 18 and 65

Exclusion Criteria:

Under the age of 18 or over the age of 65
History of seizures, seizure disorders, or epilepsy
History, signs, or symptoms concerning for or consistent with infection at the time of entry into the clinical research unit
History of malignancy currently undergoing suppressive treatment, or active malignancy
History of chronic illness such as diabetes, heart disease, hypertension, asthma/COPD, or autoimmune disease
Weight less than 110 lbs.
Blood donation within 8 weeks of study
Pregnancy
Participation in other research studies if the other study involves drugs or procedures that may impact their immune system. This determination will be made by the Investigator

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Charles Howe, Ph.D.	Closed-enrolling by invitation What is this? (?) "Close" Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.	Contact information: Jessica Sagen M.A. (507)538-3761 Sagen.Jessica@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Charles Howe, Ph.D.

Closed-enrolling by invitation

Contact information:

Jessica Sagen M.A.

(507)538-3761

Sagen.Jessica@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials