A Study of Daytime Changes in Corneas with Fuchs Dystrophy

Overview

About this study

The purpose of this study is to determine changes in corneal thickness and backscatter after first morning eye-opening across a range of fuchs endothelial dystrophy severity, and in healthy corneas. Corneal measurements will be made with a Scheimpflug camera and associated changes in visual acuity and glare (forward scatter) will be determined.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

Presence of central or paracentral corneal guttae
Any age, with expected range of 40-90 years
Any sex or race
Some normal subjects will be recruited, with normal corneas
- Absence of central or paracentral corneal guttae
- Above 50 years of age to match the predominant age of onset of FECD
- Any sex or race

Exclusion Criteria

Corneal disease (except Fuchs dystrophy in the Fuchs dystrophy group)
Previous occular surgery or refractive laser treatment
Current contact lens wear
Use of topical medications (except artificial tears) or systemic medications known to affect the cornea
Glaucoma or occular hypertension
Systemic diseases known to affect the cornea, e.g. diabetes

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Sanjay Patel, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Sanjay Patel, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

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