Study To Evaluate DNA Markers For Detection Of Primary Bladder Cancers In Urine Samples From A Cohort Of Patients With Blood in Urine

Overview

About this study

The primary objective of this study is to evaluate the performance of the methylation marker

panel for the detection of bladder cancer in patients with gross or microscopic hematuria.

The secondary objective is to evaluate the predictive accuracy of a risk model including clinical

factors such as age, gender, smoking history, and presence of gross versus microscopic hematuria compared to a model incorporating the same risk factors along with the methylation

marker panel.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Patient Eligibility

Inclusion Criteria

1. Subject is willing and able to give written informed consent

2. Subject presents with or has a history of gross hematuria or

microhematuria within the last 3 months

Exclusion Criteria

1. Subject has an active urinary tract infection, current urinary

retention, active stone disease (renal or bladder), current

ureteral stents or nephrostomy tubes, prior bowel

interposition, or recent genitourinary instrumentation (within

10 days)

2. Subject has a current or past history of genitourinary or

urologic cancer within 5 years

3. Subject has an active (untreated) cancer of any type,

except basal cell skin cancer within 5 years

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Brian Linder, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available
.
CLS-20303070

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