Cardiac Toxicity Following Radiotherapy

Overview

About this study

The purpose of this study is to determine if stress cardiac magnetic resonance imaging (MRI) imaging will allow us to detect radiation-related cardiac toxicity before other evaluation modalities would allow.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Histological confirmation of malignancy.
Patient to undergo radiotherapy with cardiac V20 > 2% or mean cardiac dose > 2 Gy.
Age ≥ 18 years.
ECOG Performance Status (PS) 0, 1 or 2.
Negative pregnancy test done ≤7 days prior to registration, for women of childbearing potential only
Ability to undergo stress cardiac MRI.
Provide informed written consent.

Exclusion Criteria:

Medical contraindication to stress cardiac MRI (including contraindication to gadolinium or
Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Nadia Laack, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Nadia Laack, M.D.

Closed for enrollment

More information

Publications

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