Topical Tranexamic Acid in Complex Cardiac Surgery: Does it Reduce Transfusion Need?

Overview

About this study

The goal of ths study is to determine the effectiveness of adding topical tranexamic acid (TXA) to our standard practice of care for patients undergoing redo or complex cardiac procedures. The study will use a control group for comparision.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Patients undergoing complex cardiac surgery (redo operations, combined operations such as CABG + valve, multiple valve).
Male or female.
Patients > 18 years of age.

Exclusion Criteria:

Patients < 18 years of age.
Patients with allergy to TXA.
Patients with prior history of thrombosis.
Patients who cannot grant informed consent.
Patients with coagulopathic conditions such as factor deficiencies, factor inhibitors, heparin induced thrombocytopenia, or use of intravenous anticoagulants other than heparin at the time of cardiovascular surgery.
Patients who have received oral therapy with clopidogrel, prasugrel, rivaroxaban or dabigatran within the past 3 days.
Patients who are taking chronic warfarin therapy who have not discontinued treatment and demonstrated an INRgreater than 1.5 prior to surgery.
Patients who are undergoing emergency open heart-surgery.
Patients for whom procedures for which the cardiopulmonary bypass time is expected to be < 30 minutes.
Patients for whom procedures for which the cardiopulmonary bypass is excepted to not be normothermic (temperature ≥ 35 degrees C).
Patients who cannot receive heparin.
Pregnant patients.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Hartzell Schaff, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Hartzell Schaff, M.D.

Closed for enrollment

More information

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