A Study of Anterior Cruciate Ligament Injury and Rehabilitation

Overview

About this study

The purpose of this study is to establish arthrogenic muscle inhibition (AMI) as a neural mechanism by examining the bilateral neuromotor drive of thigh musculature from AMI progression after anterior cruciate ligament (ACL) injury. The study will also determine the inhibitory effect of aberrant proprioceptive afferents on quadriceps and hamstring motor output. Furthermore, this study will determine the efficacy of neurofeedback to induce central changes that provide peripheral benefits to muscle activation.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Healthy, active individuals, both control subjects and individuals that are candidates for ACL reconstruction due to recent primary tearing of the ACL.

Exclusion Criteria:

Lower extremity injury/surgery in past 6 months other than ACL injury.
Neurological disorders.
Paralysis.
Neuromuscular disease.
Cardiovascular disease.
Exercise-induced injury.
Asthma.
Pregnancy.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator John Hollman, Ph.D.	Closed for enrollment
Minneapolis, Minn. Mayo Clinic principal investigator John Hollman, Ph.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

John Hollman, Ph.D.

Closed for enrollment

Minneapolis, Minn.

Mayo Clinic principal investigator

John Hollman, Ph.D.

Closed for enrollment

More information

Publications

Publications are currently not available

Clinical Trials