A Study of Platelet Rich Plasma for the Treatment of Degenerative Joint Disease of the Lumbar Spine

Overview

About this study

The purpose of this study is to determine the effectiveness and safety of using platelet rich plasma in the treatment of degenerative joint disease in the lumbar spine area.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

Clinical and radiographic evidence of symptomatic facet arthropathy involving the bilateral L4-5 and L5-S1 facets
Positive response, defined as greater than or equal to 75% pain improvement to diagnostic differential medial branch blocks, one block with lidocaine and the other with either bupivacaine or ropivacaine
Baseline pain greater than or equal to 5 (0-10 scale)

Exclusion Criteria

Recent facet related procedure
- Intraarticular corticosteroid in last 6-months
Age < 18 years
Current opioid use of greater than 100 oral morphine equivalents
No advanced imaging (MRI or CT) of the lumbar spine within the last 6-months
BMI > 34.99 (WHO class I obesity)
Active systemic or local infection
Anticoagulation with Coumadin with INR > 3.0 or Plavix with less than 7 days on hold
History of unsuccessful intra-articular injection
Imaging evidence of high likelihood of failure for intra-articular injection to be determined by a board certified staff radiologist’s review of the fluoroscopic images
Thrombocytopenia (platelet count less than 50,000)
Undergoing chemotherapy at time of injection
Pregnancy secondary to risk of ionizing radiation to the fetus

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Matthew Pingree, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Matthew Pingree, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

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