Bile Acids, Genetic Control and Ileo-Colonic Mucosal Expression in IBS-D

Overview

About this study

The purpose of this study is to understand the role of genetics (inherited genes from biological parents) and expression of genes and proteins in the lining of the intestine and colon in the development of diarrhea in patients with irritable bowel syndrome with or without bile acid malabsorption.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion criteria Asymptomatic controls IBS patients

Age (yr) 18-75 18-75

Gender (F:M) 10:1 10:1

BDQ - IBS symptoms -ve by Rome III criteria +ve by Rome III criteria

Hospital Anxiety/Depression score <8 No restrictions

Abdominal surgery (except appy or choly) None None

GI medications None past 6 months None past 48h

Exclusion criteria

In all patients diagnosed with IBS, we apply rigorous standards to exclude clinically-relevant inflammation. Patients with known bleeding diathesis will be excluded, given the need for sigmoid mucosal biopsies. Anyone with a known allergy to Midazolam and Fentanyl for Aim 2 in protocol and named medications.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Michael Camilleri, M.D., D.Sc.	Closed for enrollment	Contact information: Sanna McKinzie M.S. (507) 266-3972 McKinzie.Sanna@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Michael Camilleri, M.D., D.Sc.

Closed for enrollment

Contact information:

Sanna McKinzie M.S.

(507) 266-3972

McKinzie.Sanna@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials