Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria
Age ≥18 years, male or female
For the Colon cancer subjects: Diagnosis of stage 3 colon cancer without IBD before treatment, during treatment with 5-FU based chemotherapy and post treatment.
Normal colon participants : Normal colonoscopy without current adenomatous polyps, IBD, critical illness, obesity, celiac disease, NASH, IBS, food allergy, malnutrition or current history of diarrhea.
Polyp participants; participants with advanced adenoma (> 1cm in size; villous histology and/or high grade dysplasia without IBD
Active Chronic ulcerative colitis: participants with active CUC.
Carcinoid syndrome: participants with carcinoid syndrome.
Can swallow the mannitol capsule and drink up to 200 ml of water (or approximately 8 cups) and agrees to undergo urine testing up to 3 times during the study.
Exclusion Criteria
Participants with prior GI tract surgical (small or large bowel) resections
For normal colon participants: no h/o IBD critical illness, obesity, celiac disease, NASH, IBS, food allergy, malnutrition or current history of diarrhea.
Women who are pregnant or breast-feeding