Peripheral Neural Mechanisms of Exercise Intolerance in Heart Failure

Overview

About this study

The goal of this project is to study mechano- and- metaboreceptor function (mechanoreflex and metaboreflex, respectively) associated with exercise in HF. We will measure blood pressure, systemic vascular resistance (SVR), and the slope of the ventilatory equivalent to carbon dioxide output ratio (VE/VCO2) slope responses to stimulation of these pathways. We also aim to determine the influence of changes in blood biochemistry and intra-venous pressure on mechano- and- metaboreflex activation.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

HF Patients:
- >21 yrs
- no history of dangerous arrhythmia’s
- not be pacemaker dependent
- have a body mass index ≤35kg/m2
- currently be non-smokers with <15 pack year history
- be able to exercise (i.e. without orthopedic limitations or musculoskeletal disorders)
Control participants:
- Will be adults ≥21 years of age
- Absence of a history of HF, pulmonary, neurologic, orthopaedic, or other diseases affecting the neuromuscular system
- BMI ≤35kg/m2
- current non-smokers with smoking history <15 pack years,
- able to engage in exercise (i.e. without orthopedic limitations or musculoskeletal disorders)

Exclusion Criteria for All Participants:

History of dangerous arrhythmias
Bbody mass index >35 kg/m2
Current smokers and/or smoking history >15 pack years
Pregnant women
Individuals who are not able to engage in exercise (i.e., with orthopedic or musculoskeletal disorders/limitations
For individuals agreeing to undergo dual energy x-ray absorptiometry (DEXA) scanning for measurement of body composition as part of their study visit
- Recently administered gastrointestinal contrast or radionuclides
- Implants, hardware, devices, or other foreign material in the body
- Severe degenerative changes or fracture deformity in measurement areas
- Inability to attain correct position and/or remain motionless for the measurement period.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Thomas Olson, M.S., Ph.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Thomas Olson, M.S., Ph.D.

Closed for enrollment

More information

Publications

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