Cardiac MRE In Acute Myocardial Infarction

Overview

About this study

We have recently developed a new and novel imaging-based technique known as cardiac Magnetic Resonance Elastography (MRE) that is capable of differentiating differing regions of myocardial stiffness in the myocardium.  The condition which myocardial stiffness has been most studied and is thought to vary the most from normal is myocardial infarction. Cardiac MRE findings in acute infarction have not been established and the prognostic significance of cardiac MRE-defined infarct stiffness are unknown. The aims of this study are to compare cardiac MRE stiffness to microvascular obstruction in acute myocardial infarction, to determine the association of cardiac MRE infarct stiffness with left ventricular (LV) remodeling at approximately 6 months follow up, and to determine whether myocardial infarcts show increased stiffness at 6 months follow up.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age ≥ 18 years
  • New myocardial infarction within 10 days of enrollment

Exclusion criteria:

  •  Contraindications to MRI scanning including internal defibrillators or pacemakers, cerebral aneurysm clips, or severe claustrophobia
  • Contraindications to gadolinium-based MRI contrast material, namely glomerular filtration rate less than or equal to 30mL/min
  •  Women who are pregnant or lactating

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Philip Araoz, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available
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CLS-20306570

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