Olfactory and Sinonasal Epithelium as Cell Source of Neural Progenitors and Autologous Constructs

Overview

About this study

The goals of the study are to develop protocols for growing cells isolated from the nasal epithelium and fat tissue. This will be used to help grow nerve-related tissue as well as cartilage, epithelial cells, muscle cells, or other cells that are present in the head and neck region. The goal is to generate a large number of cells that could be used for constructing tissue that can be implanted for structural and functional reconstruction.

The development of such methods is a step in our goal to rehabilitate patients with cancer, trauma, or other debilitating neurological diseases that lose function and structure in the head and neck area. The cells isolated from your tissues will not be used for developing implants but will help with experiments to establish the protocols needed to cultivate cells and develop the implant.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

This study will enroll patients who are undergoing endoscopic endonasal skull base procedures where nasal tissue and fat is taken as standard of care. Tissue that is removed for creating surgical access, or is left behind after skull base reconstruction is usually discarded as "surgical waste". The research will involve use of this tissue.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Scottsdale/Phoenix, Ariz. Mayo Clinic principal investigator Devyani Lal, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Devyani Lal, M.D.

Closed for enrollment

More information

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