Ventricular Remodeling and Myocardial Deformation in Patients Undergoing Chemotherapy for Sarcomas

Overview

About this study

The aim of this study is to determine if there is subclinical systolic or diastolic myocardial mechanical dysfunction by 2D and 3D speckle tracking echocardiography derived strain and strain rate in this patient population at baseline, during and after chemotherapy. This could be an early marker of myocardial dysfunction in patients treated for sarcoma.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Patients followed at Mayo Clinic and treated for sarcoma with doxorubicin and/or pazopanib

Exclusion Criteria:

First-line treatment not including doxorubicin
Treatment performed outside of Mayo Clinic with different protocols
Age <18 years

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Hector Villarraga, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Hector Villarraga, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

Clinical Trials