Role of Aging and ATP in Response to Exercise

Overview

About this study

The goal of this proposal is to investigate the “compensatory” vasodilator mechanisms responsible for changes in blood flow to maintain O2 delivery to contracting muscles during exercise with hypoxia (decreased O2 content) and hyperbaric hyperoxia (increased O2 content) in healthy younger individuals compared to healthy older individuals.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Healthy young men and women (18-40 years)
Healthy older men and women (55-81 years)
Average levels of physical fitness

Exclusion Criteria:

BMI >30
Hypertension
Hyperlipidemia
Smoking
Heart disease
Diabetes
Autonomic disorders
Other conditions or medications (except birth control or at the discretion of the PI) that might normally alter exercise capacity or responses

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Timothy Curry, M.D., Ph.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Timothy Curry, M.D., Ph.D.

Closed for enrollment

More information

Publications

Publications are currently not available

Clinical Trials