Shared Biorepository for the Investigation of Inflammatory Arthritis at Mayo Clinic and University of Massachusetts

Overview

About this study

The purpose of this study is to establish a comparator cohort of patients with rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and other spondyloarthropathies. We will collect demographic information, historical information about diagnosis and past treatment, and clinical, radiographic, and laboratory data on each patient using standardized data collection forms. We will also collect blood and synovial tissue samples from each patient. This will provide data and material for clinical and translational research to address questions related to the fundamental differences between the spondyloarthropathies and inflammatory arthritis relating to the response of bone to chronic inflammation. We intend to enroll sequential patients with rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and other spondyloarthropathies who present to the Rheumatology Division at Mayo Clinic Rochester.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Rheumatoid Arthritis
- Individuals must have at least one joint with definite clinical synovitis (swelling) that is not better explained by another disease. Scores of categories A – D below will be added; a score of ≥ 6/10 is needed for inclusion in this study.
  - Joint Involvement
    - 1 large joint, 0 score
    - 2 – 10 large joints, 1 score
    - 1 – 3 small joints (with or without involvement of large joints), 2 score
    - 4 – 10 small joints (with or without involvement of large joints), 3 score
    - > 10 joints (at least 1 small joint), 5 score
  - Serology (at least one test result is needed)
    - Negative RF and Negative ACPA, 0 score
    - Low-positive RF or low-positive ACPA, 2 score
    - High-positive RF or high-positive ACPA, 3 score
  - Acute-phase reactants (at least one test result is needed)
    - Normal CRF and normal ESR, 0 score
    - Abnormal CRF or abnormal ESR, 1 score
  - Duration of symptoms
    - < 6 weeks, 0 score
    - ≥ 6 weeks, 1 score
Psoriatic Arthritis
- Individuals must have inflammatory articular disease (joint, spine, entheseal) with at least 3 of the following 5 points:
  - Evidence of psoriasis (one of a, b, c)
    - a. Current psoriasis: psoriatic skin or scalp disease currently present, as judged by a rheumatologist or a dermatologist
    - b. Personal history of psoriasis: a history of psoriasis obtained from patient or family physician, dermatologist, rheumatologist or other qualified health care professional
    - c. Family history of psoriasis: a history of psoriasis in a first or second degree relative by patient report
  - Psoriatic nail dystrophy
    - Typical psoriatic nail dystrophy, including onycholysis, pitting and hyperkeratosis observed on current physical exam
  - Negative test result for Rheumatoid Factor
    - Determined by any method except latex but preferably by ELISA or nephelometry, according to the local laboratory reference range
  - Dactylitis
    - Current (swelling of an entire digit)
    - History (a history of dactylitis recorded by a rheumatologist)
  - Radiological Evidence of juxta-articular new bone formation
    - Ill-defined ossification near joint margins - extending osteophyte formation - on plain X-ray films of hand or foot
- Axial Spondyloarthritis
  - Individuals with all of the following 3 points:
    - Back pain
      - Lasting more than 3 months
      - Age of onset less than 45 years
    - One of a, b, c
      - a. Sacroiliitis on imaging (MRI or X-ray) plus one spondyloarthropathy feature listed below (in box c)
      - b. Positive testing for HLA-B27 plus two spondyloarthropathy features listed below (in box c)
      - c. Spondyloarthropathy features:
        
        inflammatory back pain
        
        Arthritis, enthesitis (heel)
        
        Uveitis
        
        Dactylitis
        
        Psoriasis
        
        Crohn's/colitis
        
        Good response to NSAIDS
        
        Family history for spondyloarthritis
        
        HLA-B27
        
        Elevated CRP
        
        Sacroiliitis on imaging
- Peripheral Spondyloarthritis
  - Individuals that have been diagnosed with Arthritis, Enthesitis or Dactylitis AND one of criteria below:
    - At least one of the following - psoriasis, inflammatory bowel disease, preceding infection, HLA-B27, uveitis, or sacroiliitis on imaging (radiographs or MRI)
    - At least two of the following - arthritis, enthesitis, dactylitis, inflammatory back pain in the past, or a positive family history for spondyloarthritis

Exclusion Criteria:

Individuals that are under the age of 18
Prisoners
Pregnant women
Individuals that are functionally illiterate or unable to complete the questionnaires
Non-English speaking subjects

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Eric Matteson, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Eric Matteson, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

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