A Study of State-Specific Blood Marker Investigation in Bipolar and Schizoaffective Disorder

Overview

About this study

The purpose of this study is to find out if some patients with mood symptoms have antibodies (part of the immune system) that affect the brain, and could possibly play a role in the development of mood symptoms. We also want to find out if these immune markers change once your mood normalizes.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Age 18-55, male or female, any race/ethnicity
Diagnosis of
- Bipolar I disorder
  - Single manic episode
- Bipolar I disorder
  - Most recent episode hypomanic, manic, or mixed
- Bipolar II disorder
  - Most recent episode hypomanic; or schizoaffective disorder, most recent episode hypomanic, manic, or mixed
YMRS ≥12

Exclusion Criteria:

Inability to speak English
Inability or lack of willingness to provide informed consent, including current involuntary treatment or hospitalization
Outpatients with active suicidality as defined by a score of 2 or higher on question # 18 of the Inventory for Depressive Symptoms (IDS)
Active psychosis, defined by delusional thought content or hallucinations, as identified by clinical examination or on diagnostic interview.
Active or unstable medical condition as evaluated by clinical interviewer
Presence of co-morbid Axis I or Axis II disorder that is the primary diagnosis and current focus of treatment

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Robert Morgan, M.D., Ph.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Robert Morgan, M.D., Ph.D.

Closed for enrollment

More information

Publications

Publications are currently not available

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