Clinical Trials

Inclusion Criteria

POTS:

• Males or females age 18-50 years.
• Orthostatic HR increment of ≥30bpm to an absolute orthostatic HR ≥120bpm within 10 min of head-up tilt.
• Frequent orthostatic symptoms (lightheadedness, faintness), that resolve promptly with recumbency

Control Subjects:

• Males or females age 18-50 years, age and gender matched to patients
• Normal Autonomic Reflex Screen, normal Autonomic Symptom Profile

Subjects Undergoing Skin Biopsy and Autonomic Reflex Screen Only

• Males or females age 18-80 years

Exclusion Criteria

POTS and Controls

• Orthostatic hypotension (decrease of systolic BP≥30mmHg and/or diastolic BP≥15mmHg within 3min of tilt)
• Pregnant/lactating females – a pregnancy test will be required for women of childbearing potential.
• The presence of failure of other organ systems or systemic illness that can affect autonomic function.
• Concomitant therapy with anticholinergic, alpha-/beta-adrenergic antagonists or other medication which could interfere with autonomic testing. Potentially interfering medication will be held for five half-lives.

Subjects Only Undergoing Skin Biopsy and Autonomic Reflex Screen Only

• Pregnant/lactating females – a pregnancy test will be required for women of childbearing potential.
• The presence of failure of other organ systems or systemic illness that can affect autonomic function.
• Concomitant therapy with anticholinergic, alpha-/beta-adrenergic antagonists or other medication which could interfere with autonomic testing. Potentially interfering medication will be held for five half-lives.