A Study of Gluten Intolerance in Patients with Diarrhea Predominant Irritable Bowel Syndrome

Overview

About this study

The purpose of this study is to test gluten supplementation for four weeks, to see if it increases small intestinal permeability and accelerates colonic transit in patients who have irritable bowel syndrome with diarrhea (IBS-D) or functional diarrhea (FD) who are HLA-DQ2 positive.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

Diarrhea or diarrhea predominant IBS patients
Age 18 to 65
BDQ confirmed presence of IBS-D or functional diarrhea, positive by Rome III criteria
No restrictions on Hospital Anxiety Depression score
No abdominal surgery (except appendectomy and cholecystectomy)

Exclusion Criteria

Serum tissue transglutaminase IgA or IgG positive
Medical record of small bowel biopsy suggestive of celiac disease
Use of tobacco products within the past 6 months (since nicotine may affect intestinal permeability)
Use of NSAIDs or aspirin within the past week (since NSAIDs affect intestinal permeability)
Use of oral corticosteroids within the previous 6 weeks
Ingestion of artificial sweeteners such as SplendaTM (sucralose), Nutrasweet TM(aspartame), lactulose or mannitol 2 days before the study begins, e.g., foods to be avoided are sugarless gums or mints and diet soda
Ingestion of any prescription, over the counter, or herbal medications which can affect gastrointestinal transit 7 days before study begins
Any females who are pregnant or trying to become pregnant (due to radiation exposure)
Bleeding disorders or medications that increase risk of bleeding from mucosa

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Michael Camilleri, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Michael Camilleri, M.D.

Closed for enrollment

More information

Publications

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