A Study of Immune-Mediated Activation of Astrocytes in Healthy Volunteers

Overview

About this study

The purpose of this study is to characterize the astrocyte response to various inflammatory drivers in the presence of innate immune cells collected from healthy subjects. We will identify innate immune cell populations that contribute to astrocyte reactivity and elucidate the mechanisms responsible for altering the transcriptional and translational profile of astrocytes.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Healthy individuals not curently experiencing a chronic medical condition.

Exclusion Criteria:

Pregnancy
Weight less than 110 pounds
Smoker
Self-reported use of immunomodulatory or immunosuppresive drugs such as inhaled glucocorticoids within past 3 months
Self-reported history of autoimmune disease.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Charles Howe, Ph.D.	Open for enrollment	Contact information: Jessica Sagen M.A. Sagen.Jessica@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Charles Howe, Ph.D.

Open for enrollment

Contact information:

Jessica Sagen M.A.

Sagen.Jessica@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials