Clinical Trials

Inclusion Criteria:

• Female, 18-41 years of age
• Will undergo surgery, chemotherapy, drug treatment and/or radiation for the treatment or prevention of a medical condition or malignancy expected to result in permanent damage to or complete loss of subsequent ovarian function.
• Or, have a medical condition or malignancy that requires removal of all or part of one or both ovaries.
• Patients may have newly diagnosed or recurrent disease. Those who were not enrolled at the time of initial diagnosis are eligible if they have not received therapy that is viewed as likely to result in complete and permanent loss of ovarian function.
• For patients undergoing elective removal of an ovary for fertility preservation only: have two ovaries.
• Patients who already have stored cryopreserved ovarian tissue in a frozen state prior to undergoing cancer treatments (surgery, chemotherapy or radiation) will be eligible for enrollment with informed consent.
• Signed an approved informed consent and authorization permitting the release of personal health information. The patient and/or the patient’s legally authorized guardian must acknowledge in writing that consent for specimen collection has been obtained, in accordance with institutional policies approved by the U.S. Department of Health and Human Services.

Exclusion Criteria:

• Women with psychological, psychiatric, or other conditions which prevent giving fully informed consent.
• For patients undergoing elective removal of an ovary for fertility preservation only: women whose underlying medical condition significantly increases their risk of complications from anesthesia and surgery.
• Women whose underlying medical condition significantly increases their risk of complications from anesthesia and surgery.
• Women who have a large mass in the ovary that is being removed will not be enrolled in the study. That is, ovarian tissue cryopreservation will not be performed on portions of an ovary that contained a large mass as experience in this study indicates that this tissue is not suitable for patient use in the future (contains limited or no  follicles).