Clinical Trials

Inclusion Criteria

• Idiopathic Membranous Nephropathy proven by diagnostic kidney biopsy
• Age ≥18 years but ≤ 80
• Proteinuria as measured by urinary protein/urinary creatinine > 4.0 on a spot sample aliquot from a 24-hour urine collection
• Estimated GFR ≥ 30 ml/min/1.73m^2 using the 4 variable Modification of Diet in Renal Disease (MDRD) equation

Exclusion Criteria

• Age <18 years
• Estimated Glomerular Filtration Rate (GFR) < 30 ml/min/1.73m^2, or serum creatinine >3.0 mg/dl
• Must be off prednisone, calcineurin inhibitor or mycophenolate mofetil for > 1 month and alkylating agents for > 6 months
• Presence of active infection or a secondary cause of MN (e.g. hepatitis B, HIV, systemic lupus erythematosus (SLE), medications, malignancies).
• Type 1 or 2 diabetes mellitus
  • Recent history of steroid induced diabetes but no evidence of diabetic nephropathy on renal biopsy performed within 6 months of entry into the study are eligible for enrollment
• Pregnancy or nursing, for safety reasons
• Acute renal vein thrombosis documented prior to entry by renal US or CT scan
• Previous therapy with Aliskiren