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A Study of Demyelinating Lesions as a Cause of Progressive Motor Deterioration

Overview

About this study

The purpose of this study is a comprehensive review of the clinical and radiologic history in these patients as well as review of neuropathology in deceased patients, where available.  The goal of this research is to investigate the hypothesis that this presentation represents a spatially limited form of CNS inflammatory demyelinating disease.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  1. History of a single lesion in the high cervical spinal cord or lower medulla identified by presence of a T2 hyperintense MRI lesion in that location, or by pathologic examination of the brainstem and spinal cord after life
  2. History of progressive neurologic symptoms for greater than one month

Exclusion Criteria:

  1. Age <18 years
  2. MRI lesions consistent with multiple sclerosis in other portions of the central nervous system
  3. Clinical history suggesting attacks of multiple sclerosis elsewhere in the central nervous system
  4. Presence of another confirmed diagnosis expected to result in progressive myelopathy

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

B Mark Keegan, M.D.

Contact us for the latest status

Contact information:

Carey Huebert B.S.

(507)293-1120

Huebert.Carey@mayo.edu

More information

Publications

Publications are currently not available

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CLS-20314047

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