A Study of the Use of Computer Software for the Detection of Lung Diseases Over Time

Overview

About this study

The purpose of this study is to characterize lungs in normal healthy people without evidence of a pre-existing lung disease using computer software called CALIPER (Computer Aided Lung Informatics for Pathology Evaluation and Rating) and to follow the normal changes associated with aging over time.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

Age ≥ 18 years
Lifelong never-smoker (never smoked, or <100 cigarettes lifetime used and not currently using [within 30 days])
No prior history of chronic lung disease
Signed informed consent

Exclusion Criteria

BMI < 18 or > 35
Pneumonia or bronchitis within past 6 weeks
History of metallic chest hardware (sternotomy wires, metallic rib fixation, spineinstrumentation, shoulder replacements, pacemaker/defibrillator) or lung surgery
Pregnancy (based on urine pregnancy test)
History of chronic lung disease or treatment with inhaler medications, chronic heart disease (e.g. heart failure, valvular disease), connective tissue disease (e.g. lupus, rheumatoid arthritis, scleroderma, Sjögren’s, dermatomyositis/polymyositis), vasculitis, systemic malignancy
History of amiodarone, chemotherapy drugs, anti-rheumatic drugs, or prolonged use of nitrofurantoin for >6 mos
Significant home/occupational inhaled dust/smoke exposure (>12 mos asbestos, silica, beryllium; >5 years secondhand smoke)
Current or prior routine smoking of non-tobacco products >1x/month
Symptoms of chronic lung disease on ATS-DLD-78 Questionnaire
Abnormal FEV1 or FVC on baseline spirometry, or ‘unacceptable’ spirometry
Further, for patients that do obtain a CT scan, that data will be excluded from analysis if
- Lungs are deemed clinically abnormal by expert radiologist opinion
- TLCct <80% predicted physiologic TLC by standard reference calculations

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Brian Bartholmai, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Brian Bartholmai, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

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