Clinical Trials

Inclusion Criteria

1. Participants age 6-21 years enrolled in either NEPTUNE or CureGN(The lower age limit was chosen based on ability to cooperate with study-related procedures.)

2. Participants with a diagnosis of FSGS

3. Participants with a diagnosis of MCNS with active disease defined as follows:

            a) steroid dependent- relapse during corticosteroid therapy or within 2 weeks of discontinuing corticosteroids

            b) frequently relapsing- ≥2 relapses in 6 months or ≥4 relapses in 12 months or

            c) steroid resistant - failure to induce remission with corticosteroids within 8 weeks

     4.   Informed consent from the parent or guardian and assent from a minor of ≥ 7 years

   Exclusion Criteria

1. Participants with a diagnosis of IgA nephropathy, membranous nephropathy or other glomerular disease that is not FSGS or MCNS

2. Participants on dialysis or who have a kidney transplant

3. Participants with major co-morbid conditions such as cardiac disease, pulmonary disease, neurologic disease, diabetes mellitus or a genetic syndrome

4. Participants/guardians or participants who, in the opinion of the Investigator, may be non-compliant with study schedules or procedures