Clinical Trials

Inclusion Criteria:

1. Diagnosis and/or management of AAOCA at a CHSS member institution from January 1, 1998 forward
2. Male or female age 0-30 years at time of diagnosis
3. If surgical repair:
   1. Performed from January 1, 1998 to study initiation (January 20, 2009) for retrospective subjects
   2. Performed from January 21, 2009 forward for prospectively identified subjects
   3. Completed operative note
4. Structurally normal heart or with small, hemodynamically insignificant lesion, including:
   1. Patent ductus arteriosus 
   2. Atrial septal defect 
   3. Ventricular septal defect
   4. Mild pulmonic valvar stenosis 
   5. Bicuspid aortic valve without aortic stenosis
5. Parental/guardian permission (informed consent, and authorization as applicable) 
6. Subject consent, and authorization as applicable if ≥ 18 years of age and if appropriate, child assent for the observational/questionnaire portion of the study.

Exclusion Criteria:

1. Anomalous coronary from the pulmonary artery, coronary artery atresia, or other coronary artery anomalies (e.g., coronary-cameral fistula, coronary aneurysms, myocardial bridging)
2. Hemodynamically significant structural heart disease, except as outlined above.