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A Study to Assess Monoclonal B-cell Lymphocytosis in Individuals with Chronic Hepatitis C

Overview

About this study

The purpose of this study is to:

  1. To determine the prevalence of MBL in patients with chronic hepatitis C who are to begin therapy with DAA, and compare with clinic controls who are seen in the general medicine clinic at Mayo Clinic

  2. To determine the correlation between the specific subtype of MBL (CD5- MBL, atypical CLL-phenotype MBL and CLL-phenotype MBL) relative to the HCV genotype

  3. To assess the proportion of individuals with MBL who have an improvement in the circulating monoclonal B-cell population following therapy with DAA

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  1. Individuals with chronic hepatitis C who are to begin therapy with DAA
  2. Willing to submit a peripheral blood sample at baseline, 4, 12, 24, 52 and 104 weeks from start of therapy

Exclusion Criteria:

  1. Individuals with chronic hepatitis C who have cirrhosis
  2. Individuals with chronic hepatitis C who have a past history of a lymphoproliferative disorder AND for which they received chemotherapy

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Sameer Parikh, M.B.B.S.

Closed-enrolling by invitation

What is this? (?)
"Close"
Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.

Contact information:

Tanner Reicks

(507) 266-2656

Reicks.Tanner@mayo.edu

More information

Publications

Publications are currently not available

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CLS-20348507

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