Clinical Trials

Inclusion Criteria:

• Must have CDASI Activity score of greater than or equal to 14, and have failed at least 1 standard of care systemic treatment, (eg, corticosteroids).
• Confirmation of DM by the investigator and two of the following:
  1. Gottron's papules;
  2. Gottron's sign;
  3. Heliotrope eruption;
  4. Nailfold changes, (dilated capillary loops, capillary dropout, cuticular hypertrophy and/or rugged cuticles;
  5. Photodistributed violaceous erythema, (skin that is exposed to sunlight and appears purplish/reddish, and patchy in appearance;
  6. Positive DM serology.
• Post DM diagnosis; standard of care workup for DM must have been completed prior to entry into this research study.
• Willing to provide 6 biopsies during the course of the research study.

Exclusion Criteria:

• Investigator site staff or members of their family.
• Acute and Chronic present medical conditions.
• Intake of greater than 15 mg of prednisone or equivalent per day.
• Pregnant or breastfeeding females. Fertile men and women who will not comply with the use of 2 effective birth control methods as per the research protocol.
• Have required management of acute or chronic infections.
• Have pre existing demyelinating disorder such as multiple sclerosis, or other severe neurological deficits.
• Clinically significant lab abnormalities.
• Any health condition that may be worsened by immunosuppression.