Preoperative Oral Carbohydrate Drink for Elective Cesarean Delivery and the Effect on Insulin Sensitivity

Overview

About this study

Preoperative fasting and surgery can cause metabolic stress and insulin resistance. Oral carbohydrate loading has been shown to attenuate the development of insulin resistance in the non-pregnant population undergoing many different types of surgery. Pregnant women have an increase in insulin resistance and therefore may further benefit from a preoperative carbohydrate load prior to cesarean delivery. Although woman in the UK receive a carbohydrate drink prior to elective cesarean delivery, the metabolic effects of these drinks on the mother and neonate have not been evaluated.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

ASA physical status II-III women presenting for scheduled, elective cesarean delivery under neuraxial anesthesia
Singleton gestation at term (37-42 weeks)
Female, age 18-50 years old.

Exclusion Criteria:

Preexisting diabetes (Gestational diabetes, Type I DM, Type II DM).
Taking insulin-sensitizing or other medications known to influence glucose or fatty acid metabolism.
Kidney, heart, or liver disease. Severe lipid disorders.
History of bariatric surgery.
Pre-pregnancy BMI > 40.
Prolonged period of time (>4 hours) between ingestion of carbohydrate drink and surgery.
Four or more repeat cesarean sections.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Emily Sharpe, M.D.	Closed for enrollment	Contact information: Anita Stoltenberg R.R.T., L.R.T. (507)422-0582 Stoltenberg.Anita@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Emily Sharpe, M.D.

Closed for enrollment

Contact information:

Anita Stoltenberg R.R.T., L.R.T.

(507)422-0582

Stoltenberg.Anita@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials